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http://hdl.handle.net/1903/4269
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| Title: | Flow and interfacial dynamics in vascular vessels and microfluidics |
| Authors: | Wang, Yechun |
| Advisors: | Dimitrakopoulos, Panagiotis |
| Department/Program: | Chemical Engineering |
| Type: | Dissertation |
| Sponsors: | Digital Repository at the University of Maryland
University of Maryland (College Park, Md.) |
| Keywords: | Engineering, Chemical (0542)
Engineering, Mechanical (0548)
Flow; interfacial dynamics; hemodynamics; microfluidics |
| Issue Date: | 19-Jan-2007 |
| Abstract: | This dissertation investigates the hemodynamic forces on biological cells adherent on vascular vessels as well as the interfacial dynamics of droplet motion in microfluidic channels. In addition, we develop a novel three-dimensional spectral boundary element algorithm for interfacial dynamics in Stokes flow.
In physiological systems, the hemodynamic forces exerted on endothelial cells in vascular vessels affect the behavior of the cells via mechano-transduction. The hemodynamic forces also play a pivotal role in the adhesion of leukocytes onto the surface of blood vessels. This study
investigates the relative importance and the nature of the two components of the hemodynamic force, i.e., the shear and normal force, on the cell and its vicinity. Based on computational investigation and scaling analysis, the study demonstrates that the normal force contributes significantly to the total hemodynamic force on the cell. This study points out the importance of the normal force exerted on... |
| URI: | http://hdl.handle.net/1903/4269 |
| Appears in Collections: | Chemical and Biomolecular Engineering Theses and Dissertations
UM Theses and Dissertations
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| umi-umd-4135.pdf | | 5149Kb | Adobe PDF | 144 | View/Open |
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